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cenobamate will reduce the extent or result of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Increase dose of CYP3A4 substrate, as wanted, when coadministered with cenobamate.fentanyl transdermal and mirtazapine each improve sedation. Stay clear of or Use Alternate Drug. Restrict use